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Moreover, Nataraja and Bright showed that curcumin inhibited EAE decreasing IL-12 production from macrophage/microglial cells, and by inhibition of IL-12-induced tyrosine phosphorylation of Janus kinase 2 (JAK2), tyrosine kinase (TYK2), and STAT 3 and STAT4 transcription factors leads a decrease of T cell proliferation and Th1 differentiation ( in vitro and in vivo studies showed the effectiveness of curcumin against the pathogenetic mechanisms of MS, and although further evidence from randomized controlled trials on curcumin efficacy is required, its role as an effective alternative treatment was suggested ( Ginkgo biloba The study of Ginkgo biloba ( G